TP53 Arg72Pro Polymorphism and Skin Cancer Risk: A Meta-Analysis
نویسندگان
چکیده
منابع مشابه
Arg72Pro Polymorphism of TP53 Gene and the Risk of Skin Cancer: a Meta-Analysis
BACKGROUND TP53 gene is one of the most important tumor suppressor genes. We undertook this meta-analysis to explore the association between TP53 Arg72Pro polymorphism and the risk of skin cancer mainly in Caucasians. METHODS We searched PubMed for case-control studies published up to March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associa...
متن کاملTP53 Arg72Pro polymorphism and colorectal cancer risk: a systematic review and meta-analysis.
BACKGROUND The TP53 rs1042522 polymorphism (c.215C>G, Arg72Pro) has been extensively investigated as a potential risk factor for colorectal cancer, but the results have thus far been inconclusive. METHODS We searched multiple electronic databases to identify studies investigating the association between the Arg72Pro polymorphism and colorectal cancer. Individual study odds ratios (OR) and the...
متن کاملUpdated meta-analysis of the TP53 Arg72Pro polymorphism and gastric cancer risk.
OBJECTIVE The p53 tumor suppressor pathway plays an important role in gastric cancer (GC) development. Auto-regulatory feedback control of p53 expression is critical to maintaining proper tumor suppressor function. So far, several studies between p53 Arg72Pro polymorphism and GC have generated controversial and inconclusive results. METHODS To better assess the purported relationship, we perf...
متن کاملAssociation between TP53 Arg72Pro polymorphism and leukemia risk: a meta-analysis of 14 case-control studies.
The relationship between the TP53 Arg72Pro polymorphism (rs1042522) and the risk of leukemia remains controversial. Consequently, we performed a meta-analysis to accurately evaluate the association between TP53 Arg72Pro polymorphism and leukemia risk. A comprehensive search was conducted to find all eligible studies of TP53 Arg72Pro polymorphism and leukemia risk. Fourteen case-control studies,...
متن کاملAssociation between TP53 Arg72Pro polymorphism and hepatocellular carcinoma risk: a meta-analysis.
BACKGROUND Previous studies on the association between the TP53 Arg72Pro polymorphism and hepatocellular carcinoma (HCC) risk obtained controversial findings. This study aimed to quantify the strength of the association by meta-analysis. METHODS We searched PubMed and Wangfang databases for published studies on the association between the TP53 Arg72Pro polymorphism and HCC risk, using the poo...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2011
ISSN: 0022-202X
DOI: 10.1038/jid.2010.270